2. Academic Validation
  3. Identification of inhibitors of inducible nitric oxide synthase from microbial extracts

Identification of inhibitors of inducible nitric oxide synthase from microbial extracts

  • J Antibiot (Tokyo). 2000 May;53(5):496-501.
K A Alvi 1,  D D Baker,  V Stienecker,  M Hosken,  B G Nair
Affiliations

Affiliation

  • 1 MDS PANLABS, South, Bothell, WA 98011, USA.
PMID: 10908113
Abstract

A new member of the angucycline family, vineomycin C (3), together with four known metabolites saquayamycin A1 (1), A-7884 (2), rabelomycin (5) and xanthomegnin (6) were isolated from microbial extracts. The structures were determined by 1D and 2D NMR techniques and chemical degradation. Compounds 1-3 and 5 were isolated from a fermentation of Streptomyces sp., while 6 was isolated from a Fungal fermentation extract. All five compounds have shown potent inhibitory activity in the inducible nitric oxide synthase (iNOS) assay.

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