2. Academic Validation
  3. Inhibition of DNA topoisomerases by nidulalin A derivatives

Inhibition of DNA topoisomerases by nidulalin A derivatives

  • Biol Pharm Bull. 2000 Apr;23(4):511-2. doi: 10.1248/bpb.23.511.
S Sato 1,  Y Fukuda,  R Nakagawa,  T Tsuji,  K Umemura,  T Andoh
Affiliations

Affiliation

  • 1 Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
PMID: 10784438 DOI: 10.1248/bpb.23.511
Abstract

Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA Topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA Topoisomerase I with an IC50 value of 5.9 microM.

Figures
Products