2. Academic Validation
  3. Phenolic glycosides from Dirca palustris

Phenolic glycosides from Dirca palustris

  • J Nat Prod. 1999 Nov;62(11):1558-61. doi: 10.1021/np9903595.
R S Ramsewak 1,  M G Nair,  D L DeWitt,  W G Mattson,  J Zasada
Affiliations

Affiliation

  • 1 Department of Horticulture and National Food Safety and Toxicology Center, and Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824, USA.
PMID: 10579873 DOI: 10.1021/np9903595
Abstract

Five novel phenolic glycosides (1-5) were isolated from the MeOH extract of the dried twigs of Dirca palustris, as confirmed by their (1)H NMR, (13)C NMR, and MS data. Compounds 1-3 were not active against cyclooxygenase I (COX-I), but compound 4 (200 microg/mL) and compound 5 (125 microg/mL) showed 12.5 and 9.2% inhibition of the COX-I enzyme, respectively. Compounds 1-5 did not exhibit cyclooxygenase II (COX-II) enzyme inhibition. Compound 5 did not show any antioxidant activity using the Liposome assay; however, compounds 1-4 displayed antioxidant activity at 60 microg/mL, with compound 2 being the most efficacious.

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