2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. MCC-AAQ-Exa

MCC-AAQ-Exa is a drug-linker conjugates for ADC, obtained by condensing the linker with Exatecan (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs). MCC is an ADC linker containing a maleimide fragment.

For research use only. We do not sell to patients.

MCC-AAQ-Exa

MCC-AAQ-Exa Chemical Structure

CAS No. : 3052836-65-1

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Based on 1 publication(s) in Google Scholar

MCC-AAQ-Exa Related Antibodies

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Description

MCC-AAQ-Exa is a drug-linker conjugates for ADC, obtained by condensing the linker with Exatecan (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs). MCC is an ADC linker containing a maleimide fragment[1].

Molecular Weight

924.97

Formula

C47H53FN8O11
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1CCC(CC1)CN2C(C=CC2=O)=O)N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (108.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0811 mL 5.4056 mL 10.8112 mL
5 mM 0.2162 mL 1.0811 mL 2.1622 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0811 mL 5.4056 mL 10.8112 mL 27.0279 mL
5 mM 0.2162 mL 1.0811 mL 2.1622 mL 5.4056 mL
10 mM 0.1081 mL 0.5406 mL 1.0811 mL 2.7028 mL
15 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8019 mL
20 mM 0.0541 mL 0.2703 mL 0.5406 mL 1.3514 mL
25 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
30 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
40 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
50 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5406 mL
60 mM 0.0180 mL 0.0901 mL 0.1802 mL 0.4505 mL
80 mM 0.0135 mL 0.0676 mL 0.1351 mL 0.3378 mL
100 mM 0.0108 mL 0.0541 mL 0.1081 mL 0.2703 mL
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MCC-AAQ-Exa Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCC-AAQ-Exa3052836-65-1Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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