MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Name: MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
Brand: MedChemExpress
SKU: HY-132158
Rating: 4.5 (1 reviews)

Cat. No.: HY-132158 Purity: 96.00%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin Chemical Structure

CAS No. : 2414594-29-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

902.92

Formula

C₄₄H₅₁FN₈O₁₂

CAS No.

2414594-29-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(NCOCC(NCC2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C=C62)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (110.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1075 mL	5.5376 mL	11.0752 mL
5 mM	0.2215 mL	1.1075 mL	2.2150 mL
10 mM	0.1108 mL	0.5538 mL	1.1075 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.00%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) HNMR (364 KB) RP-HPLC (230 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1075 mL	5.5376 mL	11.0752 mL	27.6879 mL
	5 mM	0.2215 mL	1.1075 mL	2.2150 mL	5.5376 mL
	10 mM	0.1108 mL	0.5538 mL	1.1075 mL	2.7688 mL
	15 mM	0.0738 mL	0.3692 mL	0.7383 mL	1.8459 mL
	20 mM	0.0554 mL	0.2769 mL	0.5538 mL	1.3844 mL
	25 mM	0.0443 mL	0.2215 mL	0.4430 mL	1.1075 mL
	30 mM	0.0369 mL	0.1846 mL	0.3692 mL	0.9229 mL
	40 mM	0.0277 mL	0.1384 mL	0.2769 mL	0.6922 mL
	50 mM	0.0222 mL	0.1108 mL	0.2215 mL	0.5538 mL
	60 mM	0.0185 mL	0.0923 mL	0.1846 mL	0.4615 mL
	80 mM	0.0138 mL	0.0692 mL	0.1384 mL	0.3461 mL
	100 mM	0.0111 mL	0.0554 mL	0.1108 mL	0.2769 mL