2. Metabolic Enzyme/Protease Anti-infection
  3. Proteasome Parasite
  4. LXE408 fumarate

LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research.

For research use only. We do not sell to patients.

LXE408 fumarate

LXE408 fumarate Chemical Structure

CAS No. : 3026790-19-9

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LXE408 fumarate Related Antibodies

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Description

LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research[1].

Molecular Weight

559.51

Formula

C27H22FN7O6
CAS No.
SMILES

O=C(C1=C(C)N=C(C)O1)NC2=CC=C(F)C(C3=NN4C=C(C5=NC=CC=C5C)C=NC4=N3)=C2.O=C(O)/C=C/C(O)=O
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LXE408 fumarate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXE4083026790-19-9LXE 408LXE-408ProteasomeParasitekinetoplastidL.donovaniVisceralleishmaniasishERGInhibitorinhibitorinhibit

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