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  4. LDN193189 hydrochloride

LDN193189 hydrochloride  (Synonyms: DM-3189 hydrochloride)

Cat. No.: HY-12071C Purity: 98.62%
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LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

LDN193189 hydrochloride

LDN193189 hydrochloride Chemical Structure

CAS No. : 1062368-62-0

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Customer Review

Based on 69 publication(s) in Google Scholar

Other Forms of LDN193189 hydrochloride:

LDN193189 hydrochloride Related Antibodies

Top Publications Citing Use of Products

67 Publications Citing Use of MCE LDN193189 hydrochloride

IHC
WB

    LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jun 8;2020:4175613.  [Abstract]

    Western blot and grey analysis of CYP11a1, CYP19a1, BCL2, CALR, CHOP, caspase3, caspase12, PERK, and GRP78. qRT-PCR analyzed ATF4, caspase3, and GRP78 mRNAs. The relieving function of BMP4 on ER stress is diminished after blockade of BMP receptor I (BMPRI) with DM-3189.

    LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Cardiovasc Toxicol. 2019 Jun;19(3):264-275.  [Abstract]

    H9c2 cells are treated as following: control, DOX, DOX + rhBMP (Bmpr1a agonist) and DOX + LDN193189 (Bmpr1a inhibitor). Cells with red fluorescence indicate favorable MMP while green fluorescence indicates damage.

    • Biological Activity

    • Purity & Documentation

    • Customer Review

    Description

    LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

    In Vitro

    LDN193189 HCl is the hydrochloride salt of ldn193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation .

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    LDN193189 hydrochloride Related Antibodies
    Molecular Weight

    442.94

    Formula

    C25H23ClN6
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    [H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (56.44 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2576 mL 11.2882 mL 22.5764 mL
    5 mM 0.4515 mL 2.2576 mL 4.5153 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.2576 mL 11.2882 mL 22.5764 mL 56.4411 mL
    5 mM 0.4515 mL 2.2576 mL 4.5153 mL 11.2882 mL
    10 mM 0.2258 mL 1.1288 mL 2.2576 mL 5.6441 mL
    15 mM 0.1505 mL 0.7525 mL 1.5051 mL 3.7627 mL
    20 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8221 mL
    25 mM 0.0903 mL 0.4515 mL 0.9031 mL 2.2576 mL
    30 mM 0.0753 mL 0.3763 mL 0.7525 mL 1.8814 mL
    40 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
    50 mM 0.0452 mL 0.2258 mL 0.4515 mL 1.1288 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    LDN193189 hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LDN1931891062368-62-0DM-3189LDN 193189LDN-193189DM3189DM 3189Biochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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