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  4. LDN193189 hydrochloride

LDN193189 hydrochloride  (Synonyms: DM-3189 hydrochloride)

Cat. No.: HY-12071C
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LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

LDN193189 hydrochloride Chemical Structure

LDN193189 hydrochloride Chemical Structure

CAS No. : 1062368-62-0

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LDN193189 hydrochloride Related Antibodies

Top Publications Citing Use of Products

55 Publications Citing Use of MCE LDN193189 hydrochloride

IHC
WB

    LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jun 8;2020:4175613.  [Abstract]

    Western blot and grey analysis of CYP11a1, CYP19a1, BCL2, CALR, CHOP, caspase3, caspase12, PERK, and GRP78. qRT-PCR analyzed ATF4, caspase3, and GRP78 mRNAs. The relieving function of BMP4 on ER stress is diminished after blockade of BMP receptor I (BMPRI) with DM-3189.

    LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Cardiovasc Toxicol. 2019 Jun;19(3):264-275.  [Abstract]

    H9c2 cells are treated as following: control, DOX, DOX + rhBMP (Bmpr1a agonist) and DOX + LDN193189 (Bmpr1a inhibitor). Cells with red fluorescence indicate favorable MMP while green fluorescence indicates damage.

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    Description

    LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

    In Vitro

    LDN193189 HCl is the hydrochloride salt of ldn193189. LDN193189 is a highly potent small molecule BMP inhibitor that inhibits BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation .

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    LDN193189 hydrochloride Related Antibodies
    Molecular Weight

    442.94

    Formula

    C25H23ClN6
    CAS No.
    SMILES

    [H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
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    LDN193189 hydrochloride Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    LDN1931891062368-62-0DM-3189LDN 193189LDN-193189DM3189DM 3189Biochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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