2. Immunology/Inflammation
  3. NO Synthase
  4. Kihadanin A

Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA)[3].

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Kihadanin A

Kihadanin A Chemical Structure

CAS No. : 125276-62-2

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Kihadanin A Related Antibodies

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nNOS iNOS eNOS

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Description

Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA)[1][2][3].

IC50 & Target

iNOS3[2]
Molecular Weight

486.51

Formula

C26H30O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]34[C@](C(O[C@](C5=CC(OC5O)=O)([H])[C@@]4(CC[C@]1([H])[C@@]6([C@@](C(C)(OC(C=C6)=O)C)([H])CC2=O)C)C)=O)([H])O3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (102.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0555 mL 10.2773 mL 20.5546 mL
5 mM 0.4111 mL 2.0555 mL 4.1109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0555 mL 10.2773 mL 20.5546 mL 51.3864 mL
5 mM 0.4111 mL 2.0555 mL 4.1109 mL 10.2773 mL
10 mM 0.2055 mL 1.0277 mL 2.0555 mL 5.1386 mL
15 mM 0.1370 mL 0.6852 mL 1.3703 mL 3.4258 mL
20 mM 0.1028 mL 0.5139 mL 1.0277 mL 2.5693 mL
25 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0555 mL
30 mM 0.0685 mL 0.3426 mL 0.6852 mL 1.7129 mL
40 mM 0.0514 mL 0.2569 mL 0.5139 mL 1.2847 mL
50 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0277 mL
60 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8564 mL
80 mM 0.0257 mL 0.1285 mL 0.2569 mL 0.6423 mL
100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5139 mL
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Kihadanin A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kihadanin A125276-62-2NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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