2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. JTE-151

JTE-151 is a RORγ inhibitor, which can suppress overactive immune response through inhibition of RORγ related to the activation of Th17 cells, making JTE-151 possible to be used in autoimmune disease research.

For research use only. We do not sell to patients.

JTE-151 Chemical Structure

JTE-151 Chemical Structure

CAS No. : 1404380-58-0

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Based on 1 publication(s) in Google Scholar

JTE-151 Related Antibodies

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RORγ RORα RORβ

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Description

JTE-151 is a RORγ inhibitor, which can suppress overactive immune response through inhibition of RORγ related to the activation of Th17 cells, making JTE-151 possible to be used in autoimmune disease research[1].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
2.3 μM
Compound: 53
Agonist activity at human RoRc-LBD expressed in CHO cells assessed as transcriptional activity by GAL4 reporter assay
Agonist activity at human RoRc-LBD expressed in CHO cells assessed as transcriptional activity by GAL4 reporter assay
[PMID: 24502334]
Molecular Weight

501.06

Formula

C28H37ClN2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=CC(C)=CC=C1NC(C[C@H](CCC(O)=O)C2=NOC([C@@H]3C[C@H](CC(C)(C)C)C3)=C2C4CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (49.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9958 mL 9.9788 mL 19.9577 mL
5 mM 0.3992 mL 1.9958 mL 3.9915 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9958 mL 9.9788 mL 19.9577 mL 49.8942 mL
5 mM 0.3992 mL 1.9958 mL 3.9915 mL 9.9788 mL
10 mM 0.1996 mL 0.9979 mL 1.9958 mL 4.9894 mL
15 mM 0.1331 mL 0.6653 mL 1.3305 mL 3.3263 mL
20 mM 0.0998 mL 0.4989 mL 0.9979 mL 2.4947 mL
25 mM 0.0798 mL 0.3992 mL 0.7983 mL 1.9958 mL
30 mM 0.0665 mL 0.3326 mL 0.6653 mL 1.6631 mL
40 mM 0.0499 mL 0.2495 mL 0.4989 mL 1.2474 mL
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JTE-151 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JTE-1511404380-58-0JTE151JTE 151RORRAR-related orphan receptorROR-γ inhibitorTh17 cellautoimmune diseasepsoriasisrheumatoid arthritismultiple sclerosisinflammatory bowel diseasesInhibitorinhibitorinhibit

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