2. Isotope-Labeled Compounds
  3. Isotope-Labeled Nucleic Acids

Isotope-Labeled Nucleic Acids

Nucleic acids, comprising of nucleobases, nucleosides, and nucleotides, are biopolymers, macromolecules, essential to all known forms of life. The two main classes of nucleic acids are deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which serve as the genetic information-carrying molecules. MedChemExpress ( MCE ) offers various Stable Isotope-Labeled nucleic acids and derivatives to assist protein structural analysis and DNA/RNA related researches.

Isotope-Labeled Nucleic Acids (125):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0617S
    S-Adenosyl-L-methionine-d3 68684-40-2 99.55%
    S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.
    S-Adenosyl-L-methionine-d<sub>3</sub>
  • HY-19528S
    SAH-d4 ≥99.0%
    SAH-d4 is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM.
    SAH-d<sub>4</sub>
  • HY-F0004S
    β-Nicotinamide mononucleotide-d4 99.55%
    β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.
    β-Nicotinamide mononucleotide-d<sub>4</sub>
  • HY-16938S1
    5'-Methylthioadenosine-d3 174838-38-1 99.90%
    5'-Methylthioadenosine-d3 is the deuterium labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis.
    5'-Methylthioadenosine-d<sub>3</sub>
  • HY-B0152S1
    Adenine-13C 86967-48-8 99.75%
    Adenine-13C is the 13C labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
    Adenine-<sup>13</sup>C
  • HY-N0091S7
    Hypoxanthine-15N4 77910-30-6 98.50%
    Hypoxanthine-15N4 is the 15N labeled Hypoxanthine. Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
    Hypoxanthine-<sup>15</sup>N<sub>4</sub>
  • HY-122524S
    7-Methylguanosine-d3 98.54%
    7-Methylguanosine-d3 is the deuterium labeled 7-Methylguanosine. 7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor with IC50 value of 87.8 ± 7.5 μM.
    7-Methylguanosine-d<sub>3</sub>
  • HY-D0184S2
    2'-Deoxycytidine-15N3 99.70%
    2'-Deoxycytidine-15N3 is the 15N labeled 2'-Deoxycytidine. 2'-Deoxycytidine, a deoxyribonucleoside, could inhibit biological effects of Bromodeoxyuridine (Brdu).
    2'-Deoxycytidine-<sup>15</sup>N<sub>3</sub>
  • HY-150792S
    Inosine-15N4 204634-01-5 98.40%
    Inosine-15N4 is the 15N labeled Inosine.
    Inosine-<sup>15</sup>N<sub>4</sub>
  • HY-I0960S9
    Uracil-d4 24897-55-0 99.94%
    Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d<sub>4</sub>
  • HY-B0228S
    Adenosine-d 109923-50-4 99.72%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine-d
  • HY-B1449S
    Uridine-15N2 92487-68-8 98.00%
    Uridine-15N2 is the 15N labeled Uridine.
    Uridine-<sup>15</sup>N<sub>2</sub>
  • HY-19312S
    3-Methyladenine-d3 110953-39-4 99.44%
    3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K.
    3-Methyladenine-d<sub>3</sub>
  • HY-B1511S
    Cyclic AMP-13C5 2170095-23-3
    Cyclic AMP-13C5 is a deuterated cyclic AMP.
    Cyclic AMP-<sup>13</sup>C<sub>5</sub>
  • HY-B0152S
    Adenine-d 109923-52-6 99.90%
    Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
    Adenine-d
  • HY-N1150S1
    Thymidine-d4 347841-67-2 ≥99.0%
    Thymidine-d4 is the deuterium labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
    Thymidine-d<sub>4</sub>
  • HY-N0097S3
    Guanosine-15N5 99.60%
    Guanosine-15N5 is the 15N labeled Guanosine. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
    Guanosine-<sup>15</sup>N<sub>5</sub>
  • HY-I0960S1
    Uracil-13C4 98.00%
    Uracil-13C4 is the 13C labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-<sup>13</sup>C<sub>4</sub>
  • HY-B1743S
    Puromycin-d3 98.96%
    Puromycin-d3 is the deuterium labeled Puromycin. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.
    Puromycin-d<sub>3</sub>
  • HY-A0181S
    Adenosine monophosphate-13C10,15N5 dilithium ≥99.0%
    Adenosine monophosphate-13C10,15N5(AMP-13C10,15N5) is the 13C-labeled and 15N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.
    Adenosine monophosphate-<sup>13</sup>C<sub>10</sub>,<sup>15</sup>N<sub>5</sub> dilithium