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  5. Isobornyl acetate

Isobornyl acetate is a compound with an aroma. Isobornyl acetate can be used as a food additive for food flavoring. Isobornyl acetate can also be used as a fragrance in products such as perfumes, cosmetics, and detergents.

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Isobornyl acetate

Isobornyl acetate Chemical Structure

CAS No. : 125-12-2

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Other Forms of Isobornyl acetate:

Isobornyl acetate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Isobornyl acetate is a compound with an aroma. Isobornyl acetate can be used as a food additive for food flavoring. Isobornyl acetate can also be used as a fragrance in products such as perfumes, cosmetics, and detergents[1][2].

In Vivo

Isobornyl acetate (15-270 mg/kg; oral gavage; 13 weeks) has certain toxicity to rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Weanling CFE rats[1]
Dosage: 15, 90 and 270 mg/kg
Administration: Oral gavage; 13 weeks
Result: Caused no differences in the rate of body-weight gain, the food intake or the results of haematological investigations.
Decreased renal concentrating ability, increased water intake, exfoliation of renal tubular cells, increased kidney weight and vacuolation of the renal tubular cells in male rats given 270 mg/kg/day.
Caused signs of nephrotoxicity at 90 mg/kg.
Caused vacuolation of the epithelium of the intrahepatic bile-duct, increased liver weights and enlarged caeca at 270 mg/kg.
Caused no-effect level of 15 mg/kg, more than a hundred times the calculated maximum intake by man.
Molecular Weight

196.29

Formula

C12H20O2
CAS No.
Appearance

Liquid (Density: 0.983 g/cm3)

Color

Colorless to light yellow

SMILES

C[C@@]12[C@H](C[C@H](CC2)C1(C)C)OC(C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (509.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0945 mL 25.4725 mL 50.9450 mL
5 mM 1.0189 mL 5.0945 mL 10.1890 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.74 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0945 mL 25.4725 mL 50.9450 mL 127.3626 mL
5 mM 1.0189 mL 5.0945 mL 10.1890 mL 25.4725 mL
10 mM 0.5095 mL 2.5473 mL 5.0945 mL 12.7363 mL
15 mM 0.3396 mL 1.6982 mL 3.3963 mL 8.4908 mL
20 mM 0.2547 mL 1.2736 mL 2.5473 mL 6.3681 mL
25 mM 0.2038 mL 1.0189 mL 2.0378 mL 5.0945 mL
30 mM 0.1698 mL 0.8491 mL 1.6982 mL 4.2454 mL
40 mM 0.1274 mL 0.6368 mL 1.2736 mL 3.1841 mL
50 mM 0.1019 mL 0.5095 mL 1.0189 mL 2.5473 mL
60 mM 0.0849 mL 0.4245 mL 0.8491 mL 2.1227 mL
80 mM 0.0637 mL 0.3184 mL 0.6368 mL 1.5920 mL
100 mM 0.0509 mL 0.2547 mL 0.5095 mL 1.2736 mL
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Isobornyl acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isobornyl125-12-2Othersfood additivefragranceInhibitorinhibitorinhibit

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