2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. IQM-266

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a KD of 4.63 μM. IQM-266 inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD).

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IQM-266

IQM-266 Chemical Structure

CAS No. : 1956337-58-8

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IQM-266 Related Antibodies

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Description

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a KD of 4.63 μM. IQM-266 inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD)[1].

In Vitro

IQM-266 (0-100 μM) concentration-dependently inhibits Kv4.3/DREAM channels (IC50 = 8.6 μM) in CHO cells by slowing their activation and inactivation kinetics[1].
IQM-266 (0-100 μM) inhibits the maximum peak current and, to a lesser extent, the charge crossing the cell membrane during depolarization at ≥ 10 μM in CHO cells[1].
IQM-266 (3 μM) increases the charge through the cell membrane during the application of depolarizing pulses, and inhibits peak Kv4.3/DREAM current amplitude while slowing its inactivation in CHO cells[1].
IQM-266 (3-10 μM) slows the recovery process and increases closed-state inactivation of Kv4.3/DREAM channels in a concentration-dependent manner in CHO cells through its specific interaction with DREAM, which also underlies the observed increase in transmembrane charge[1].
IQM-266 (3-10 μM) dose-dependently reduces the peak amplitude of IA in rat DRG neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IQM-266 Related Antibodies
Molecular Weight

397.42

Formula

C25H19NO4
CAS No.
SMILES

O=C(NC1=CC(C=CC=C2)=C2C=C1C(O)=O)CC3=CC(OC4=CC=CC=C4)=CC=C3
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Purity & Documentation
References
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IQM-266 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQM-2661956337-58-8IQM266IQM 266Potassium ChannelKcsADREAMKV4.3DRG neuronsneurological diseaseAlzheimerHuntingtonInhibitorinhibitorinhibit

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