Ionizable lipid-1 hydrochloride 

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure^[1].

Ionizable lipid-1 hydrochloride can be protonated and positively charged at acidic pH. Ionizable lipid-1 hydrochloride electrostatically binds to negatively charged RNA molecules, thereby encapsulating RNA into nanoparticles. Ionizable lipid-1 hydrochloride will be protonated again once entering cells, interacts with the negatively charged endosome membrane. The interaction leads to the disruption of the endosome membrane, thereby releasing the RNA payload into the cytoplasm^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

956.00

C₅₈H₁₁₅ClN₂O₅

[H]Cl.O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Thomas D Madden, et al. Lamellar lipid nanoparticles. Patent WO2019089828A1.

  [2]. Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1941-E1950.  [Content Brief]