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  6. Indomethacin sodium

Indomethacin sodium  (Synonyms: INDOMETHACIN SODIUM)

Cat. No.: HY-15034
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Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research..

For research use only. We do not sell to patients.

Indomethacin sodium Chemical Structure

Indomethacin sodium Chemical Structure

CAS No. : 7681-54-1

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Indomethacin sodium Related Antibodies

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53 Publications Citing Use of MCE Indomethacin sodium

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Description

Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research.[1][2][3].

IC50 & Targetsup>[1]

COX-1

18 nM (IC50)

COX-2

26 nM (IC50)

In Vitro

Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro[2].
Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC50=2μM)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Indomethacin sodium Related Antibodies

Cell Viability Assay[2]

Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration: 0, 20, 50, 100 and 150 μM
Incubation Time: 24 hours
Result: Inhibited cell viability at 20 mM, with 50% inhibition at 60 nM.

Cell Cycle Analysis[2]

Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells)
Concentration: 0, 30 and 80 μM
Incubation Time: 24 hours
Result: Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.
In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Indomethacin can be used to induce gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. Typically, the plasma peak concentration (2-3 μg/mL) is reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma[4].

Induction of gastric ulceration[5][6]
Background
Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.
Specific Modeling Methods
Rat: albino Sprague-Dawley • male • adult (period: 2 weeks)
Administration: 100 mg/kg • p.o. • single dose
Note
(1) All animals fasted 24 h before drug administration.
(2) Indomethacin were dissolved in saline with 5% NaOH.
Modeling Indicators
Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)
Opposite Product(s): Carnosic acid (HY-N0644)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.01-10 mg/kg
Administration: Oral administration; for 3 hours
Result: Inhibited the carrageenan-induced rat paw oedema (ED50=2.0 mg/kg) and hyperalgesia (ED50=1.5 mg/kg) in a dose-dependent manner.
Animal Model: Male C57BL/6J mice[2]
Dosage: 10 mg/mL
Administration: Oral administration; daily, for 29 days
Result: Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
Clinical Trial
Molecular Weight

379.77

Formula

C19H15ClNNaO4
CAS No.
SMILES

O=C(O[Na])CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Indomethacin sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indomethacin7681-54-1INDOMETHACINCOXAntibioticInfluenza VirusBacterialCyclooxygenaseanti-infectiveanticancerinflammationCOX-1COX-2Inhibitorinhibitorinhibit

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