IL-17A modulator-3

Name: IL-17A modulator-3
Brand: MedChemExpress
SKU: HY-148272
Rating: 4.5 (1 reviews)

Cat. No.: HY-148272 Purity: 99.10%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

IL-17A modulator-3 (compound 253) is a IL-17A modulator. IL-17A modulator-3 inhibits IL-17A/A with an IC₅₀ value ＜10 μM. IL-17A modulator-3 can be used for the research of inflammation, cancer and autoimmune disease.

For research use only. We do not sell to patients.

IL-17A modulator-3 Chemical Structure

CAS No. : 2467732-95-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

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View All Interleukin Related Isoform Specific Products:

View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: ＜10 μM (IL-17A/A)^[1]

In Vitro

IL-17A modulator-3 (0-10 μM; 20 h) inhibits IL-17A/A with an IC₅₀ value ＜10 μM in HEK-Blue IL-17A reporter cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

639.80

Formula

C₃₄H₅₀FN₇O₄

CAS No.

2467732-95-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=NN1C(C)C)N[C@@H]([C@H]2CC[C@H](C)CC2)C(NC3=CC=C([C@H](C)[C@@H](NC(CC)=O)C(N4CCN(C)CC4)=O)C=C3F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (78.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5630 mL	7.8149 mL	15.6299 mL
5 mM	0.3126 mL	1.5630 mL	3.1260 mL
10 mM	0.1563 mL	0.7815 mL	1.5630 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.10%

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Data Sheet (272 KB) SDS (251 KB)

COA (252 KB) HNMR (320 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Fatheree, Paul R, et al. Amidoamide ligands as IL-17 modulators and their preparation. US20200247785. 2020.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5630 mL	7.8149 mL	15.6299 mL	39.0747 mL
	5 mM	0.3126 mL	1.5630 mL	3.1260 mL	7.8149 mL
	10 mM	0.1563 mL	0.7815 mL	1.5630 mL	3.9075 mL
	15 mM	0.1042 mL	0.5210 mL	1.0420 mL	2.6050 mL
	20 mM	0.0781 mL	0.3907 mL	0.7815 mL	1.9537 mL
	25 mM	0.0625 mL	0.3126 mL	0.6252 mL	1.5630 mL
	30 mM	0.0521 mL	0.2605 mL	0.5210 mL	1.3025 mL
	40 mM	0.0391 mL	0.1954 mL	0.3907 mL	0.9769 mL
	50 mM	0.0313 mL	0.1563 mL	0.3126 mL	0.7815 mL
	60 mM	0.0260 mL	0.1302 mL	0.2605 mL	0.6512 mL