2. Others Cell Cycle/DNA Damage
  3. Others Topoisomerase
  4. IKE16

IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection.

For research use only. We do not sell to patients.

IKE16

IKE16 Chemical Structure

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IKE16 Related Antibodies

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Topoisomerase Topo I Topo II

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Description

IKE16 is a fungi-selective eukaryotic topoisomerase II inhibitor, with an IC50 value of 13.68 μM. IKE16 suppresses both the DNA relaxation activity and the decatenation activity of yTOPOII selectively. IKE16 shows moderate activity against standard fungal strains (Candida albicans ATCC 10231, Saccharomyces cerevisiae ATCC 89763) with a minimum inhibitory concentration (MIC) of 2 μg/mL against S. cerevisiae ATCC 89763. IKE16 exhibits high cytotoxicity against human cells, with an EC50 of 0.07 μM in HepG2 and 0.045 μM in HEK-293. IKE16 can be used for the study of antifungal infection[1].

IC50 & Target[1]

Topoisomerase II

13.68 μM (IC50)

Molecular Weight

644.72

Formula

C36H36N8O4
SMILES

O=[N+](C1=CC=CC2=NC3=CC=CC=C3C(NCCCN4CCN(CCCNC5=C(C([N+]([O-])=O)=CC=C6)C6=NC7=CC=CC=C75)CC4)=C21)[O-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IKE16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKE16IKE 16IKE-16OthersTopoisomerasetopoisomerase IIantifungal infectionHEK-293HepG2Inhibitorinhibitorinhibit

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