2. GPCR/G Protein
  3. GHSR
  4. Ibutamoren

Ibutamoren  (Synonyms: MK-677 free base; MK-0677 free base)

Cat. No.: HY-10199A Purity: 98.52%
COA
SDS
Handling Instructions Technical Support

Ibutamoren (MK-677) is an orally active growth hormone secretagogue receptor (GHSR) agonist and a nonpeptide growth hormone secretagogue. Ibutamoren can be used for metabolic research.

For research use only. We do not sell to patients.

Ibutamoren Chemical Structure

Ibutamoren Chemical Structure

CAS No. : 159634-47-6

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Ibutamoren:

Ibutamoren Related Antibodies

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GHSR1a

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Description

Ibutamoren (MK-677) is an orally active growth hormone secretagogue receptor (GHSR) agonist and a nonpeptide growth hormone secretagogue. Ibutamoren can be used for metabolic research[1].

Clinical Trial
Molecular Weight

528.66

Formula

C27H36N4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N1C2=C(C(CCN3C([C@@H](COCC4=CC=CC=C4)NC(C(C)(C)N)=O)=O)(CC3)C1)C=CC=C2)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (118.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8916 mL 9.4579 mL 18.9157 mL
5 mM 0.3783 mL 1.8916 mL 3.7832 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.52%

SDS (393 KB)

COA (258 KB) HNMR (337 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8916 mL 9.4579 mL 18.9158 mL 47.2894 mL
5 mM 0.3783 mL 1.8916 mL 3.7832 mL 9.4579 mL
10 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7289 mL
15 mM 0.1261 mL 0.6305 mL 1.2611 mL 3.1526 mL
20 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
25 mM 0.0757 mL 0.3783 mL 0.7566 mL 1.8916 mL
30 mM 0.0631 mL 0.3153 mL 0.6305 mL 1.5763 mL
40 mM 0.0473 mL 0.2364 mL 0.4729 mL 1.1822 mL
50 mM 0.0378 mL 0.1892 mL 0.3783 mL 0.9458 mL
60 mM 0.0315 mL 0.1576 mL 0.3153 mL 0.7882 mL
80 mM 0.0236 mL 0.1182 mL 0.2364 mL 0.5911 mL
100 mM 0.0189 mL 0.0946 mL 0.1892 mL 0.4729 mL
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Ibutamoren Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ibutamoren159634-47-6MK-677MK-0677MK677MK 677MK0677MK 0677GHSRGrowth hormone secretagogue receptorGhrelin receptorGH secretagogue,Inhibitorinhibitorinhibit

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