1. TGF-beta/Smad
  2. TGF-β Receptor
  3. HYL001

HYL001 (compund 338) is a potent inhibitor of TGFβ receptor 1 (ALK5) that is approximately 9 times more potent than the structurally related compound Galunisertib (HY-13226) and is able to eliminate liver metastases established in mice.

For research use only. We do not sell to patients.

HYL001 Chemical Structure

HYL001 Chemical Structure

CAS No. : 2426547-83-1

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Description

HYL001 (compund 338) is a potent inhibitor of TGFβ receptor 1 (ALK5) that is approximately 9 times more potent than the structurally related compound Galunisertib (HY-13226) and is able to eliminate liver metastases established in mice[1].

IC50 & Target

TGFβ[1]

Molecular Weight

342.39

Formula

C21H18N4O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC2=C(C3=C(CCC4)N4N=C3C5=CC=CC(C)=N5)C=CN=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.5 mg/mL (51.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9206 mL 14.6032 mL 29.2065 mL
5 mM 0.5841 mL 2.9206 mL 5.8413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9206 mL 14.6032 mL 29.2065 mL 73.0161 mL
5 mM 0.5841 mL 2.9206 mL 5.8413 mL 14.6032 mL
10 mM 0.2921 mL 1.4603 mL 2.9206 mL 7.3016 mL
15 mM 0.1947 mL 0.9735 mL 1.9471 mL 4.8677 mL
20 mM 0.1460 mL 0.7302 mL 1.4603 mL 3.6508 mL
25 mM 0.1168 mL 0.5841 mL 1.1683 mL 2.9206 mL
30 mM 0.0974 mL 0.4868 mL 0.9735 mL 2.4339 mL
40 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8254 mL
50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.4603 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
HYL001
Cat. No.:
HY-160237
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