Hexaamminecobalt(III) chloride (Synonyms: Cobalt hexammine trichloride; Hexaamminecobalt trichloride)

Cat. No.: HY-W075903 Purity: 99.50%: Data Sheet
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Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma.

For research use only. We do not sell to patients.

Hexaamminecobalt(III) chloride Chemical Structure

CAS No. : 10534-89-1

Size	Stock	Quantity
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
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Description

In Vivo

Hexaamminecobalt (III) chloride (5-20 mg/kg; i.p.; once daily; 3 consecutive days) accumulates maximally in the kidney of Balb/c mice, causes higher toxicity in the kidney than in the liver via inducing oxidative stress, and impairs kidney function in a dose-dependent manner^[1].
Hexaamminecobalt (III) chloride (100 ppm; p.o. via drinking water; 14 weeks) exerts anticarcinogenic effects against Diethylnitrosamine (HY-N7434)-induced hepatocarcinogenesis in BALB/c mice^[2].
Hexaamminecobalt (III) chloride (10-20 mg/kg body weight; i.p.; 3 consecutive days) reduces cell viability of preneoplastic liver lesions in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino BALB/c mice (average body weight 20-25 g,); DENA-induced hepatocarcinogenesis model^[2]
Dosage:	100 ppm in drinking water
Administration:	Oral administration via drinking water, 14 weeks
Result:	Showed significant recovery in body weight gain. Significantly reduced the relative liver weight. Reversed the abnormal activities of serum and liver tumor marker enzymes (GGT, LDH). Reduced lipid peroxidation (decreased MDA levels) and restored the levels/activities of antioxidant parameters (GSH, SOD, CAT) and detoxifying enzyme GST in the liver.

Molecular Weight

267.48

Formula

Cl₃CoH₁₈N₆

CAS No.

10534-89-1

Appearance

Solid

Color

Brown to orange

SMILES

ClClCl.[Co].N.N.N.N.N.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (186.93 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7386 mL	18.6930 mL	37.3860 mL
5 mM	0.7477 mL	3.7386 mL	7.4772 mL
10 mM	0.3739 mL	1.8693 mL	3.7386 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.50%

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Data Sheet (272 KB) SDS (419 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Naura AS, et al. Toxic effects of hexaammine cobalt(III) chloride on liver and kidney in mice: Implication of oxidative stress. Drug Chem Toxicol. 2009;32(3):293-9. [Content Brief]

[2]. Naura AS, et al. Anticarcinogenic effects of hexaamminecobalt(III) chloride in mice initiated with diethylnitrosamine. Biol Trace Elem Res. 2007 Nov;119(2):147-65. [Content Brief]

[3]. Naura AS, et al. Studies on mode of action of hexaammine Co(III) chloride against diethylnitrosamine-induced hepatocarcinogenesis in mice. J Biochem Mol Toxicol. 2009 May-Jun;23(3):193-201. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7386 mL	18.6930 mL	37.3860 mL	93.4649 mL
	5 mM	0.7477 mL	3.7386 mL	7.4772 mL	18.6930 mL
	10 mM	0.3739 mL	1.8693 mL	3.7386 mL	9.3465 mL
	15 mM	0.2492 mL	1.2462 mL	2.4924 mL	6.2310 mL
	20 mM	0.1869 mL	0.9346 mL	1.8693 mL	4.6732 mL
	25 mM	0.1495 mL	0.7477 mL	1.4954 mL	3.7386 mL
	30 mM	0.1246 mL	0.6231 mL	1.2462 mL	3.1155 mL
	40 mM	0.0935 mL	0.4673 mL	0.9346 mL	2.3366 mL
	50 mM	0.0748 mL	0.3739 mL	0.7477 mL	1.8693 mL
	60 mM	0.0623 mL	0.3115 mL	0.6231 mL	1.5577 mL
	80 mM	0.0467 mL	0.2337 mL	0.4673 mL	1.1683 mL
	100 mM	0.0374 mL	0.1869 mL	0.3739 mL	0.9346 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Hexaamminecobalt(III) chloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hexaamminecobalt(III)10534-89-1Cobalt hexammine trichloride Hexaamminecobalt trichlorideBiochemical Assay ReagentsSODGlutathione S-transferaseSuperoxide DismutaseGlutathione transferasesGSTsanti-carcinogenicmicepreneoplastichepatocarcinogenesisInhibitorinhibitorinhibit

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Hexaamminecobalt(III) chloride (Synonyms: Cobalt hexammine trichloride; Hexaamminecobalt trichloride)

Hexaamminecobalt(III) chloride Related Antibodies

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