2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Guvacine hydrobromide

Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively.

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Guvacine hydrobromide

Guvacine hydrobromide Chemical Structure

CAS No. : 6027-92-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Guvacine hydrobromide:

Guvacine hydrobromide Related Antibodies

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Description

Guvacine hydrobromide, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine hydrobromide inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1].

IC50 & Target

IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1]
Molecular Weight

208.05

Formula

C6H10BrNO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CCCNC1)O.[H]Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Guvacine hydrobromide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guvacine6027-92-5GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGAT-1GAT-2GAT-3BGT-1β-alaninealanineanticonvulsantInhibitorinhibitorinhibit

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