2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Guanadrel

Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies.

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Guanadrel Chemical Structure

Guanadrel Chemical Structure

CAS No. : 40580-59-4

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Based on 1 publication(s) in Google Scholar

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Description

Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].

In Vivo

Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats, dogs[1]
Dosage: 15-400 mg/kg
Administration: Oral gavage; every day; 6-52 weeks
Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats.
Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.
Molecular Weight

213.28

Formula

C10H19N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(=N)NCC1OC2(CCCCC2)OC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Guanadrel Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanadrel40580-59-4Adrenergic ReceptorBeta Receptoranti-hypertensivepostganglionic adrenergic inhibitorInhibitorinhibitorinhibit

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