GR–14-3-3 stabilizer-1

Cat. No.: HY-169905 Purity: 99.61%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3.

For research use only. We do not sell to patients.

GR–14-3-3 stabilizer-1 Chemical Structure

CAS No. : 271798-59-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glues targeting glucocorticoids (GR) and block the interaction between GR and 14-3-3^[1].

Molecular Weight

317.79

Formula

C₁₅H₁₂ClN₃OS

CAS No.

271798-59-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1NN=C(CSC2=CC=C(C=C2)Cl)N1C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 71.43 mg/mL (224.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1467 mL	15.7337 mL	31.4673 mL
5 mM	0.6293 mL	3.1467 mL	6.2935 mL
10 mM	0.3147 mL	1.5734 mL	3.1467 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (253 KB) HNMR (260 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Perry M, et al. Rational discovery of molecular glues for the glucocorticoid receptor–14-3-3 protein-protein interaction starting with application of traditional hit-finding methods[J]. 2024.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1467 mL	15.7337 mL	31.4673 mL	78.6683 mL
	5 mM	0.6293 mL	3.1467 mL	6.2935 mL	15.7337 mL
	10 mM	0.3147 mL	1.5734 mL	3.1467 mL	7.8668 mL
	15 mM	0.2098 mL	1.0489 mL	2.0978 mL	5.2446 mL
	20 mM	0.1573 mL	0.7867 mL	1.5734 mL	3.9334 mL
	25 mM	0.1259 mL	0.6293 mL	1.2587 mL	3.1467 mL
	30 mM	0.1049 mL	0.5245 mL	1.0489 mL	2.6223 mL
	40 mM	0.0787 mL	0.3933 mL	0.7867 mL	1.9667 mL
	50 mM	0.0629 mL	0.3147 mL	0.6293 mL	1.5734 mL
	60 mM	0.0524 mL	0.2622 mL	0.5245 mL	1.3111 mL
	80 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.9834 mL
	100 mM	0.0315 mL	0.1573 mL	0.3147 mL	0.7867 mL