RHOBTB1 - Rho related BTB domain containing 1 Gene

Homo sapiens

Gene ID: 9886 | Gene type: protein coding

About RHOBTB1

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:60,860,860-61,001,967 (from NCBI)

This gene has 6 transcripts (splice variants), 164 orthologues and 22 paralogues. Broad expression in placenta (RPKM 10.3), kidney (RPKM 7.3) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

RHOBTB1 Products(12)

mRNA	Protein	Name
NM_001242359.2	NP_001229288.1	rho-related BTB domain-containing protein 1 isoform 1
NM_001350902.2	NP_001337831.1	rho-related BTB domain-containing protein 1 isoform 1
NM_001350903.2	NP_001337832.1	rho-related BTB domain-containing protein 1 isoform 1
NM_001350904.2	NP_001337833.1	rho-related BTB domain-containing protein 1 isoform 1
NM_001350905.2	NP_001337834.1	rho-related BTB domain-containing protein 1 isoform 1
NM_001350906.2	NP_001337835.1	rho-related BTB domain-containing protein 1 isoform 2
NM_001350907.2	NP_001337836.1	rho-related BTB domain-containing protein 1 isoform 2
NM_001350908.2	NP_001337837.1	rho-related BTB domain-containing protein 1 isoform 2
NM_001350909.2	NP_001337838.1	rho-related BTB domain-containing protein 1 isoform 2
NM_001350910.2	NP_001337839.1	rho-related BTB domain-containing protein 1 isoform 2
NM_001350911.2	NP_001337840.1	rho-related BTB domain-containing protein 1 isoform 2
NM_014836.5	NP_055651.1	rho-related BTB domain-containing protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOBTB1 Protein Structure

Ras

BTB

0
200
400
600
696 a.a.

Protein Preferred Names

Protein Names

rho-related BTB domain-containing protein 1

RHOBTB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RHOBTB1	O94844	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	RHOBTB1	O94844	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	RHOBTB1	O94844	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	RHOBTB1	O94844	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	RHOBTB1	O94844	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	RHOBTB1	O94844	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	RHOBTB1	O94844	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	RHOBTB1	O94844	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	RHOBTB1	O94844	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	RHOBTB1	O94844	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	RHOBTB1	O94844	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	RHOBTB1	O94844	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ascaridiasis

Ascariasis

Toxic Megacolon

Megacolon, Toxic	Toxic Dilatation Of Colon
Toxic Functional Megacolon

Clostridium Difficile Colitis

Pseudomembranous Colitis	Colitis Pseudomembranous
Enterocolitis, Pseudomembranous	Pseudomembranous Enterocolitis
Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11947	RHOBTB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RHOBTB1	VGNC	VGNC:33945
Rattus norvegicus	RHOBTB1	RGD	RGD:1306871
Macaca mulatta	RHOBTB1	VGNC	VGNC:76768
Mus musculus	RHOBTB1	MGD	MGI:1916538
Canis familiaris	RHOBTB1	VGNC	VGNC:45556
Felis catus	RHOBTB1	VGNC	VGNC:64613

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