2. Gene
  3. Ptges2 - prostaglandin E synthase 2 Gene

Ptges2 - prostaglandin E synthase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gbf1; Pges2; Mpges2; 0610038H10Rik

Gene ID: 96979 | Gene type: protein coding

About Ptges2

Summary

The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]

Ptges2 Products(1)

mRNA Protein Name
NM_133783.2 NP_598544.2 prostaglandin E synthase 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
12050152 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12050152 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
12050152 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12050152 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin E synthase 2

GATE-binding factor 1

mPGES-2

microsomal prostaglandin E synthase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11380 PTGES2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19804 Ptges2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26300 Ptges2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptges2 NCBI NCBI:80142