2. Gene
  3. TRAM2 - translocation associated membrane protein 2 Gene

TRAM2 - translocation associated membrane protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9697 | Gene type: protein coding

About TRAM2

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,497,408-52,577,060 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 2 paralogues. Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues.

Summary

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

TRAM2 Products(1)

mRNA Protein Name
NM_012288.4 NP_036420.1 translocating chain-associated membrane protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14749390 GOA
Biological Process GO Annotation Evidence Reference Source
involved in collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
14749390 GOA
involved in protein insertion into ER membrane IDA
IDA: Inferred from direct assay
27499293 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAM2 Protein Structure

TRAM1

TRAM1: TRAM1-like protein (48 - 111)

TRAM_LAG1_CLN8

TRAM_LAG1_CLN8: TLC domain (113 - 311)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

translocating chain-associated membrane protein 2

TRAM-like protein

TRAM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83080 TRAM2 Antibody (YA2825) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Epilepsy, Myoclonic Juvenile

Juvenile Myoclonic Epilepsy

Janz Syndrome

Jme

Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

EJM

Myoclonic Epilepsy, Juvenile

Petit Mal, Impulsive

Myoclonic Epilepsy, Juvenile 1

Myoclonic Epilepsy, Juvenile, 1

Adolescent Myoclonic Epilepsy

Juvenile Myoclonus Epilepsy

Juvenile Myoclonic Epilepsy 1

EJM1

Petit Mal Impulsive

Susceptibility To Juvenile Myoclonic Epilepsy 1

Myoclonic Epilepsy Juvenile

Epilepsy, Myoclonic, Juvenile

Myoclonic Epilepsy Of Janz

Jme - [Juvenile Myoclonic Epilepsy]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14982 TRAM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRAM2 VGNC VGNC:54242
Rattus norvegicus TRAM2 RGD RGD:1589151
Macaca mulatta TRAM2 VGNC VGNC:83515
Felis catus TRAM2 VGNC VGNC:102540
Canis familiaris TRAM2 VGNC VGNC:49104
Mus musculus TRAM2 MGD MGI:1924817