2. Gene
  3. Prg4 - proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Gene

Prg4 - proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MSF; SZP; CACP; JCAP; DOL54; lubricin

Gene ID: 96875 | Gene type: protein coding

About Prg4

Summary

Predicted to enable polysaccharide binding activity and scavenger receptor activity. Acts upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Located in extracellular space. Is expressed in brain; larynx; musculoskeletal system; and spinal component of peripheral nervous system. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]

Prg4 Products(2)

mRNA Protein Name
NM_001110146.1 NP_001103616.1 proteoglycan 4 isoform 2 precursor
NM_021400.3 NP_067375.3 proteoglycan 4 isoform 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21939632 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15719068 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
15719068 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proteoglycan 4

megakaryocyte-stimulating factor

proteoglycan 3

superficial zone proteoglycan

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11090 PRG4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19634 Prg4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26129 Prg4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99690 Ledelabricin alfa / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prg4 NCBI NCBI:10216