TTLL4 - tubulin tyrosine ligase like 4 Gene

Homo sapiens

Gene ID: 9654 | Gene type: protein coding

About TTLL4

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,710,835-218,759,724 (from NCBI)

This gene has 21 transcripts (splice variants), 180 orthologues and 12 paralogues. Broad expression in testis (RPKM 10.4), brain (RPKM 3.1) and 24 other tissues.

Summary

Predicted to enable tubulin binding activity and tubulin-glutamic acid Ligase activity. Predicted to be involved in microtubule Cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]

TTLL4 Products(1)

mRNA	Protein	Name
NM_014640.5	NP_055455.3	tubulin monoglutamylase TTLL4

TTLL4 Protein Structure

TTL

0
200
400
600
800
1000
1199 a.a.

Protein Preferred Names

Protein Names

tubulin monoglutamylase TTLL4

protein monoglutamylase TTLL4

Related Diseases

Diseases

Alias

Nephronophthisis 2

NPHP2	Nph2
Nephronophthisis 2, Infantile	Infantile Nephronophthisis 2
Infantile Nephronophthisis	Nephronophthisis, Type 2

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15231	TTLL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TTLL4	VGNC	VGNC:54382
Bos taurus	TTLL4	VGNC	VGNC:36492
Felis catus	TTLL4	VGNC	VGNC:80394
Rattus norvegicus	TTLL4	RGD	RGD:1594742
Mus musculus	TTLL4	MGD	MGI:1914784
Macaca mulatta	TTLL4	VGNC	VGNC:79758

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