2. Gene
  3. Smpd3 - sphingomyelin phosphodiesterase 3 Gene

Smpd3 - sphingomyelin phosphodiesterase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as cca1

Gene ID: 94338 | Gene type: protein coding

About Smpd3

Summary

Predicted to enable identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of cellular biosynthetic process; and positive regulation of exosomal secretion. Located in cytoplasm and membrane. Used to study pulmonary hypertension and transient cerebral ischemia. Biomarker of chronic obstructive pulmonary disease. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Smpd3 Products(1)

mRNA Protein Name
NM_053605.2 NP_446057.2 sphingomyelin phosphodiesterase 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24007266 RGD
Biological Process GO Annotation Evidence Reference Source
involved in artery smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
19088082 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
17693623 RGD
involved in dopamine uptake IMP
IMP: Inferred from mutant phenotype
20096352 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
20096352 RGD
involved in positive regulation of ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
20096352 RGD
involved in positive regulation of exosomal secretion IMP
IMP: Inferred from mutant phenotype
24743145 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
14720208 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
14720208 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 3

confluent 3Y1 cell-associated 1

confluent 3Y1 cell-associated protein 1

nSMase-2

nSMase2

neutral sphingomyelin phosphodiesterase 3

neutral sphingomyelinase 2

neutral sphingomyelinase II

sphingomyelin phosphodiesterase 3, neutral membrane

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13449 SMPD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21047 Smpd3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27565 Smpd3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd3 NCBI NCBI:55512