2. Gene
  3. Rpe65 - retinoid isomerohydrolase RPE65 Gene

Rpe65 - retinoid isomerohydrolase RPE65 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 89826 | Gene type: protein coding

About Rpe65

Summary

Enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Involved in several processes, including circadian rhythm; neural retina development; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Apr 2022]

Rpe65 Products(1)

mRNA Protein Name
NM_053562.3 NP_446014.2 retinoid isomerohydrolase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IMP
IMP: Inferred from mutant phenotype
21785167 RGD
Biological Process GO Annotation Evidence Reference Source
involved in camera-type eye development IEP
IEP: Inferred from expression pattern
9512345 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
12742352 RGD
involved in neural retina development IDA
IDA: Inferred from direct assay
2631392 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
17389522 RGD
involved in retinal metabolic process IMP
IMP: Inferred from mutant phenotype
21785167 RGD
involved in retinol metabolic process IDA
IDA: Inferred from direct assay
3603006 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell body IDA
IDA: Inferred from direct assay
19180257 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

retinoid isomerohydrolase

RPE65, retinoid isomerohydrolase

all-trans-retinyl-palmitate hydrolase

lutein isomerase

meso-zeaxanthin isomerase

retinal pigment epithelium 65

retinal pigment epithelium 65-like

retinal pigment epithelium-specific 65 kDa protein

retinal pigment ep

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-19720 Emixustat 98.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149325 RPE65-IN-1 ≥98.0% Unkown
HY-RS12151 RPE65 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22780 Rpe65 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS29294 Rpe65 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpe65 NCBI NCBI:6121