2. Gene
  3. Rfc1 - replication factor C subunit 1 Gene

Rfc1 - replication factor C subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Recc1

Gene ID: 89809 | Gene type: protein coding

About Rfc1

Summary

Enables double-stranded DNA binding activity; protein domain specific binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleolus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Rfc1 Products(1)

mRNA Protein Name
NM_053547.1 NP_445999.1 replication factor C subunit 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11356826 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
9826522 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7729533 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11356826 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9826522 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9826522 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9677428 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
9826522 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11356826 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11356826 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

replication factor C subunit 1

replication factor C (activator 1) 1

replication factor C 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11865 RFC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13047 SLC19A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22297 Rfc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28820 Rfc1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rfc1 NCBI NCBI:5981