2. Gene
  3. Sfrp4 - secreted frizzled-related protein 4 Gene

Sfrp4 - secreted frizzled-related protein 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 89803 | Gene type: protein coding

About Sfrp4

Summary

Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted Frizzled related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp4 Products(1)

mRNA Protein Name
NM_053544.2 NP_445996.2 secreted frizzled-related protein 4 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18567805 RGD
Biological Process GO Annotation Evidence Reference Source
involved in decidualization IEP
IEP: Inferred from expression pattern
12063187 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
16540541 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
9409757 RGD
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
18567805 RGD
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12952927 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18567805 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12063187 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
16540541 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12960062 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12960062 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

secreted frizzled-related protein 4

DDC-4 protein

FRP

frizzled related protein

sFRP-4

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12776 SFRP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17510 Sfrp4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23967 Sfrp4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp4 NCBI NCBI:6424
Mus musculus Sfrp4 NCBI NCBI:20379