2. Gene
  3. Twist1 - twist family bHLH transcription factor 1 Gene

Twist1 - twist family bHLH transcription factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Twist

Gene ID: 85489 | Gene type: protein coding

About Twist1

Summary

Predicted to enable several functions, including E-box binding activity; bHLH transcription factor binding activity; and protein homodimerization activity. Involved in several processes, including odontogenesis; positive regulation of epithelial cell proliferation; and roof of mouth development. Located in nucleus. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Twist1 Products(1)

mRNA Protein Name
NM_053530.2 NP_445982.1 twist-related protein 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in bone development IEP
IEP: Inferred from expression pattern
8773900 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
19893041 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
10485844 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19893041 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19276370 RGD
involved in roof of mouth development IEP
IEP: Inferred from expression pattern
11330859 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twist-related protein 1

twist basic helix-loop-helix transcription factor 1

twist gene homolog 1

twist homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2013 Aristolactam I 99.31% Unkown
HY-RS15281 TWIST1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20201 Twist1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26705 Twist1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twist1 NCBI NCBI:7291