2. Gene
  3. SMAD9 - Smad9 SMAD family member 9 Gene

SMAD9 - Smad9 SMAD family member 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Madh9; Smad8

Gene ID: 85435 | Gene type: protein coding

About SMAD9

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including Mullerian duct regression; positive regulation of transcription, DNA-templated; and response to hypoxia. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of heteromeric SMAD protein complex. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human SMAD9 (Smad Family member 9). [provided by Alliance of Genome Resources, Apr 2022]

SMAD9 Products(1)

mRNA Protein Name
NM_138872.2 NP_620227.2 mothers against decapentaplegic homolog 9
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9371779 RGD
Biological Process GO Annotation Evidence Reference Source
involved in Mullerian duct regression IMP
IMP: Inferred from mutant phenotype
16687449 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9371779 RGD
involved in positive regulation of cell differentiation IDA
IDA: Inferred from direct assay
16585960 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17515860 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 9

MAD homolog 9

SMAD 9

mothers against DPP homolog 9

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13399 SMAD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19036 Smad9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25525 Smad9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SMAD9 NCBI NCBI:4093