Xpo1 - exportin 1 Gene

Rattus norvegicus

Also known as exp1

Gene ID: 85252 | Gene type: protein coding

About Xpo1

Summary

Enables protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II; protein export from nucleus; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including annulate lamellae; kinetochore; and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]

Xpo1 Products(1)

mRNA	Protein	Name
NM_053490.2	NP_445942.1	exportin-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	27013579	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10438867	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11689633	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to salt	IEP IEP: Inferred from expression pattern	27013579	RGD
involved in cellular response to triglyceride	IEP IEP: Inferred from expression pattern	27013579	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11689633	RGD
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	11689633	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11689633	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

exportin-1

chromosome region maintenance 1 protein homolog	exportin 1 (CRM1, yeast, homolog)
exportin 1, CRM1 homolog

Xpo1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Xpo1	Q80U96	NS2	Murine minute virus	P0DJZ2	Anti Bait CoIP	10438867

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100423	Eltanexor	Inhibitor	99.84%	Phase 2
HY-15970	Verdinexor		99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164710	Biotinylated leptomycin B		99.32%	Unkown
HY-RS15889	XPO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-144763	XPO1-IN-1	Inducer	/	Unkown
HY-161391	CW0134	Modulator	/	Unkown
HY-161392	CW2158	Modulator	/	Unkown
HY-170669	PROTAC XPO1 degrader-1		/	Unkown
HY-170671	E3 ligase Ligand 49		/	Unkown
HY-170672	XPO1-ligand-1	Ligand	/	Unkown
HY-170673	E3 Ligase Ligand-linker Conjugate 156		/	Unkown
HY-163902	SP100030 analogue 1	Inhibitor	/	Unkown
HY-RS16700	Xpo1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23134	Xpo1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xpo1	NCBI	NCBI:7514

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