Ncoa3 - nuclear receptor coactivator 3 Gene

Rattus norvegicus

Also known as Aib1; Tram-1

Gene ID: 84584 | Gene type: protein coding

About Ncoa3

Summary

Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including male gonad development; positive regulation of intracellular Estrogen receptor signaling pathway; and regulation of transcription, DNA-templated. Located in Golgi apparatus; nucleus; and perinuclear region of cytoplasm. Used to study breast Cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa3 Products(1)

mRNA	Protein	Name
NM_053454.1	NP_445906.1	nuclear receptor coactivator 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15166231	RGD
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	17223690	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	11818503	RGD
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	11713241	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	20132223	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	20132223	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellum development	IEP IEP: Inferred from expression pattern	10803578	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	16189181	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21454665	RGD
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11713241	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	21454665	RGD
involved in positive regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	11713241	RGD
involved in positive regulation of intracellular steroid hormone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16179382	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17481888	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16179382	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor coactivator 3

AIB-1	NCoA-3
amplified in breast cancer-1 protein homolog	thyroid hormone receptor activator molecule 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09091	NCOA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20451	Ncoa3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26960	Ncoa3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncoa3	NCBI	NCBI:8202

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