Dgat1 - diacylglycerol O-acyltransferase 1 Gene

Rattus norvegicus

Also known as ARAT; Dgat

Gene ID: 84497 | Gene type: protein coding

About Dgat1

Summary

Enables diacylglycerol O-acyltransferase activity; diacylglycerol binding activity; and fatty acid binding activity. Involved in several processes, including Insulin secretion; positive regulation of hepatic stellate cell activation; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle and plasma membrane. Biomarker of chronic kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Dgat1 Products(1)

mRNA	Protein	Name
NM_053437.2	NP_445889.2	diacylglycerol O-acyltransferase 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acyltransferase activity	IMP IMP: Inferred from mutant phenotype	18768481	RGD
enables diacylglycerol O-acyltransferase activity	IDA IDA: Inferred from direct assay	12193544	RGD
enables diacylglycerol binding	IDA IDA: Inferred from direct assay	14596837	RGD
enables fatty acid binding	IDA IDA: Inferred from direct assay	14596837	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycerolipid metabolic process	IDA IDA: Inferred from direct assay	12193544	RGD
involved in insulin secretion	IMP IMP: Inferred from mutant phenotype	12193544	RGD
involved in ketone body metabolic process	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	18000880	RGD
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	23449193	RGD
involved in regulation of intestinal lipid absorption	IMP IMP: Inferred from mutant phenotype	18768481	RGD
involved in regulation of vitamin A metabolic process	IMP IMP: Inferred from mutant phenotype	18000880	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	17032584	RGD
involved in triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	14596837	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

diacylglycerol O-acyltransferase 1

acyl-CoA retinol O-fatty-acyltransferase	acyl-coenzyme A:diacylglycerol acyltransferase 1
diacylglycerol acyltransferase	diglyceride acyltransferase
retinol O-fatty-acyltransferase

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16278	Pradigastat	Inhibitor	98.88%	Phase 3
HY-13009	PF-04620110	Inhibitor	99.60%	Phase 1
HY-15497	AZD7687	Inhibitor	99.80%	Phase 1
HY-123765	JTT-553	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10038	A 922500	Inhibitor	99.33%	Unkown
HY-32219	T863	Inhibitor	99.83%	Unkown
HY-12425	DGAT1-IN-1	Inhibitor	≥98.0%	Unkown
HY-141572	1,2-Dioleoyl-sn-glycerol		99.96%	Unkown
HY-50861	AZD3988	Inhibitor	99.83%	Unkown
HY-50670	DGAT-1 inhibitor 2	Inhibitor	95.70%	Unkown
HY-15197	ABT-046	Inhibitor	98.57%	Unkown
HY-16434	DGAT1-IN-3	Inhibitor	99.92%	Unkown
HY-111417	GSK2973980A	Inhibitor	/	Unkown
HY-112851	Diacylglycerol acyltransferase inhibitor-1	Inhibitor	/	Unkown
HY-118386	H2-005		/	Unkown
HY-16088	BAY 74-4113	Inhibitor	/	Unkown
HY-16278A	Pradigastat sodium	Inhibitor	/	Unkown
HY-N7281	Aphadilactone C	Inhibitor	/	Unkown
HY-RS03710	DGAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-136707	DGAT-1 inhibitor 3	Inhibitor	/	Unkown
HY-16266	JNJ-DGAT1-A	Inhibitor	/	Unkown
HY-N9153A	Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether		/	Unkown
HY-RS16667	Dgat1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23102	Dgat1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dgat1	NCBI	NCBI:8694

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