2. Gene
  3. SLC4A4 - Slc4a4 solute carrier family 4 member 4 Gene

SLC4A4 - Slc4a4 solute carrier family 4 member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as KNBC; NBC2; Nbc1; Nbc4; PNBC; HHNMC; HNBC1; SLC4A5

Gene ID: 84484 | Gene type: protein coding

About SLC4A4

Summary

Predicted to enable identical protein binding activity and sodium:bicarbonate symporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and sodium ion export across plasma membrane. Located in membrane. Used to study nephrogenic diabetes insipidus. Biomarker of hypertension. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Apr 2022]

SLC4A4 Products(1)

mRNA Protein Name
NM_053424.1 NP_445876.1 electrogenic sodium bicarbonate cotransporter 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables sodium:bicarbonate symporter activity IDA
IDA: Inferred from direct assay
9486238 RGD
enables sodium:bicarbonate symporter activity IMP
IMP: Inferred from mutant phenotype
12604466 RGD
Biological Process GO Annotation Evidence Reference Source
involved in metanephric proximal tubule development IEP
IEP: Inferred from expression pattern
30645697 RGD
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
10069984 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electrogenic sodium bicarbonate cotransporter 1

NBC-like protein

Na(+)/HCO3(-) cotransporter

Na+HCO3- cotransporter 4

sodium bicarbonate cotransporter

solute carrier family 4 (anion exchanger), member 4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13270 SLC4A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19074 Slc4a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25564 Slc4a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens SLC4A4 NCBI NCBI:8671