Bnip3 - BCL2 interacting protein 3 Gene

Rattus norvegicus

Gene ID: 84480 | Gene type: protein coding

About Bnip3

Summary

Enables identical protein binding activity. Involved in several processes, including cardiac muscle cell apoptotic process; central nervous system development; and positive regulation of cell death. Located in dendrite; mitochondrion; and nucleoplasm. Used to study congestive heart failure. Biomarker of several diseases, including cerebrovascular disease (multiple); chronic obstructive pulmonary disease; end stage renal disease; obesity; and retinal detachment. Orthologous to human BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Bnip3 Products(1)

mRNA	Protein	Name
NM_053420.3	NP_445872.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25436615	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	25436615	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagic cell death	IMP IMP: Inferred from mutant phenotype	19539716	RGD
involved in cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12226479	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	28661226	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	19539716	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17379825	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	16765336	RGD
involved in negative regulation of mitochondrial membrane permeability involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17980495	RGD
involved in negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	17980495	RGD
involved in neuron apoptotic process	IDA IDA: Inferred from direct assay	14972662	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	12787069	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16645637	RGD
involved in positive regulation of autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	23698117	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IDA IDA: Inferred from direct assay	23028672	RGD
involved in positive regulation of mitochondrial calcium ion concentration	IMP IMP: Inferred from mutant phenotype	25489073	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	22639046	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	20157446	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	14972662	RGD
involved in response to oxygen-glucose deprivation	IEP IEP: Inferred from expression pattern	22639046	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14972662	RGD
located in dendrite	IDA IDA: Inferred from direct assay	14972662	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	14972662	RGD
located in nucleus	IDA IDA: Inferred from direct assay	14972662	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

BCL2/adenovirus E1B 19 kDa-interacting protein 3

BCL2/adenovirus E1B interacting protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01564	BNIP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121859	RU28362	Agonist	/	Unkown
HY-RS01565	BNIP3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16291	Bnip3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18697	Bnip3l Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23202	Bnip3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25184	Bnip3l Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bnip3	NCBI	NCBI:664

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