Enpp2 - ectonucleotide pyrophosphatase/phosphodiesterase 2 Gene

Rattus norvegicus

Gene ID: 84050 | Gene type: protein coding

About Enpp2

Summary

Enables lysophospholipase activity; metal ion binding activity; and phosphoric diester hydrolase activity. Involved in several processes, including cellular response to estradiol stimulus; estrous cycle; and regulation of cell-substrate adhesion. Located in Golgi apparatus and extracellular space. Orthologous to human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). [provided by Alliance of Genome Resources, Apr 2022]

Enpp2 Products(1)

mRNA	Protein	Name
NM_057104.3	NP_476445.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alkylglycerophosphoethanolamine phosphodiesterase activity	IDA IDA: Inferred from direct assay	24747415	RGD
enables calcium ion binding	IDA IDA: Inferred from direct assay	21240271	RGD
enables lysophospholipase activity	IDA IDA: Inferred from direct assay	12354767	RGD
enables phosphodiesterase I activity	IMP IMP: Inferred from mutant phenotype	17307740	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	21240271	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	17307740	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	24361405	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	18946176	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	22122904	RGD
involved in negative regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	12837632	RGD
involved in phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	21240271	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12119361	RGD
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	22139091	RGD
involved in positive regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	22139091	RGD
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	22139091	RGD
involved in response to polycyclic arene	IEP IEP: Inferred from expression pattern	25490995	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12837632	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 2

E-NPP 2	autotaxin
extracellular lysophospholipase D	lysoPLD
phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145344	ONO-8430506	Inhibitor	99.68%	Unkown
HY-143582	ATX inhibitor 9	Inhibitor	/	Unkown
HY-146124	ATX inhibitor 21	Inhibitor	/	Unkown
HY-RS04388	ENPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17381	Enpp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23836	Enpp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Enpp2	NCBI	NCBI:5168

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