2. Gene
  3. Pon1 - paraoxonase 1 Gene

Pon1 - paraoxonase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 84024 | Gene type: protein coding

About Pon1

Summary

Enables aryldialkylphosphatase activity. Involved in several processes, including response to fatty acid; response to fluoride; and response to nutrient levels. Located in extracellular space and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and hematologic Cancer (multiple). Orthologous to human PON1 (paraoxonase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pon1 Products(1)

mRNA Protein Name
NM_032077.1 NP_114466.1 serum paraoxonase/arylesterase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables aryldialkylphosphatase activity IDA
IDA: Inferred from direct assay
11015468 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
23383120 RGD
involved in response to fluoride IDA
IDA: Inferred from direct assay
24384758 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
29174038 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21562236 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23644946 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
16214326 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serum paraoxonase/arylesterase 1

A-esterase 1

PON 1

aromatic esterase 1

serum aryldialkylphosphatase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143239 PPARα/γ agonist 1 Agonist 99.69% Unkown
HY-W015892 γ-Hexalactone 99.77% Unkown
HY-130220 (±)5-HETE lactone / Unkown
HY-146058 NF-κB/PON1-IN-1 Inhibitor / Unkown
HY-B0815S Chlorpyrifos-d10 Inhibitor ≥98.0% Unkown
HY-RS10872 PON1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17965 Pon1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24436 Pon1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W017445 Homogentisic acid lactone Inhibitor 98.32% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pon1 NCBI NCBI:5444