2. Gene
  3. NAE1 - Nae1 NEDD8 activating enzyme E1 subunit 1 Gene

NAE1 - Nae1 NEDD8 activating enzyme E1 subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Appbp1; RGD1563180

Gene ID: 84019 | Gene type: protein coding

About NAE1

Summary

Predicted to enable NEDD8 activating enzyme activity; protein heterodimerization activity; and ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint signaling; neuron apoptotic process; and protein neddylation. Located in early endosome and membrane raft. Biomarker of middle cerebral artery infarction. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

NAE1 Products(1)

mRNA Protein Name
NM_032072.4 NP_114461.3 NEDD8-activating enzyme E1 regulatory subunit
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
17611268 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NEDD8-activating enzyme E1 regulatory subunit

APP-binding protein 1

amyloid beta precursor protein-binding protein 1, 59 kDa

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133558 VII-31 Activator 99.63% Unkown
HY-RS09007 NAE1 Human Pre-designed siRNA Set A / Unkown
HY-161268 NAE-IN-1 99.75% Unkown
HY-RS17023 Nae1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23466 Nae1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NAE1 NCBI NCBI:8883