Grip1 - glutamate receptor interacting protein 1 Gene

Rattus norvegicus

Gene ID: 84016 | Gene type: protein coding

About Grip1

Summary

Enables signaling receptor binding activity. Involved in dendrite arborization; positive regulation of neuron projection arborization; and protein transport. Located in neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Grip1 Products(1)

mRNA	Protein	Name
NM_032069.1	NP_114458.1	glutamate receptor-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	21847098	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	17084383	RGD
enables ionotropic glutamate receptor binding	IDA IDA: Inferred from direct assay	11007883	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	10896157	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9647694	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	21847098	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16037816	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IDA IDA: Inferred from direct assay	14597197	RGD
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	11007883	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	14597197	RGD
involved in dendrite arborization	IMP IMP: Inferred from mutant phenotype	15965473	RGD
involved in negative regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	12597860	RGD
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	11931740	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	15965473	RGD
involved in positive regulation of neuron projection arborization	IGI IGI: Inferred from genetic interaction	25424568	RGD
involved in positive regulation of neuron projection arborization	IMP IMP: Inferred from mutant phenotype	15965473	RGD
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17207582	RGD
involved in regulation of kainate selective glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	12597860	RGD
involved in regulation of synaptic scaling	IMP IMP: Inferred from mutant phenotype	26109571	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15226318	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15912503	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	17626212	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	17626212	RGD
located in dendritic spine head	IDA IDA: Inferred from direct assay	11007883	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	11007883	RGD
part of exocyst	IDA IDA: Inferred from direct assay	26109571	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10436050	RGD
located in glutamatergic synapse	IDA IDA: Inferred from direct assay	15226318	RGD
located in microtubule	IDA IDA: Inferred from direct assay	15226318	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	1041498	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15226318	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	9069286	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	18315564	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	10436050	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	15226318	RGD
located in presynapse	IDA IDA: Inferred from direct assay	26109571	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	15912503	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	15226318	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	11978826	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	20956289	RGD
located in spine synapse	IDA IDA: Inferred from direct assay	11007883	RGD
located in synaptic cleft	IDA IDA: Inferred from direct assay	26109571	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	15912503	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15226318	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor-interacting protein 1

AMPA receptor-interacting protein GRIP1

GRIP-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05809	GRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09090	NCOA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19007	Grip1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19721	Ncoa2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25496	Grip1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26217	Ncoa2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grip1	NCBI	NCBI:23426

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