2. Gene
  3. Trps1 - transcriptional repressor GATA binding 1 Gene

Trps1 - transcriptional repressor GATA binding 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D15Ertd586e

Gene ID: 83925 | Gene type: protein coding

About Trps1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Involved in hair follicle development and regulation of chondrocyte differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; negative regulation of transcription, DNA-templated; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skin. Used to study trichorhinophalangeal syndrome type I. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Apr 2022]

Trps1 Products(3)

mRNA Protein Name
NM_001310481.1 NP_001297410.1 zinc finger transcription factor Trps1 isoform 1
NM_001310485.1 NP_001297414.1 zinc finger transcription factor Trps1 isoform 3
NM_032000.2 NP_114389.2 zinc finger transcription factor Trps1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12444977 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
18363966 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
18363966 MGI
involved in hair follicle development IMP
IMP: Inferred from mutant phenotype
23133399 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23133399 MGI
acts upstream of or within negative regulation of DNA-templated transcription IPI
IPI: Inferred from physical interaction
12444977 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
18363966 MGI
involved in regulation of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19389374 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
18363966 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger transcription factor Trps1

trichorhinophalangeal syndrome I

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D0168 Orcinol 99.97% Unkown
HY-N0637A (±)-Eriodictyol ≥99.0% Unkown
HY-N2983 Cajanin Inhibitor 99.96% Unkown
HY-134046 (-)-Isodocarpin Inhibitor 99.78% Unkown
HY-N10016 Chlorogenic acid butyl ester Inhibitor 98.19% Unkown
HY-N0113A Hordenine sulfate / Unkown
HY-RS15119 TRPS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19749 Trps1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26246 Trps1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trps1 NCBI NCBI:7227