2. Gene
  3. Nr5a1 - nuclear receptor subfamily 5, group A, member 1 Gene

Nr5a1 - nuclear receptor subfamily 5, group A, member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Sf-1; Ad4bp; Ftzf1; Ad4BP/SF-1

Gene ID: 83826 | Gene type: protein coding

About Nr5a1

Summary

Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including calcineurin-mediated signaling; positive regulation of male gonad development; and response to gonadotropin-releasing hormone. Located in nucleus. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in 46,XX sex reversal 4; 46,XY sex reversal 3; Zellweger syndrome; primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr5a1 Products(1)

mRNA Protein Name
NM_001191099.2 NP_001178028.1 steroidogenic factor 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12697699 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
12697699 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12697699 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcineurin-mediated signaling IMP
IMP: Inferred from mutant phenotype
25057110 RGD
involved in female gonad development IEP
IEP: Inferred from expression pattern
12865342 RGD
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
25057110 RGD
involved in positive regulation of male gonad development IMP
IMP: Inferred from mutant phenotype
16467257 RGD
involved in response to gonadotropin-releasing hormone IEP
IEP: Inferred from expression pattern
17344471 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12697699 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

steroidogenic factor 1

STF-1

adrenal 4-binding protein

fushi tarazu factor homolog 1

steroid hormone receptor Ad4BP

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115613 ML-180 Agonist 99.96% Unkown
HY-107404 SID 7969543 Inhibitor 99.42% Unkown
HY-131445 RJW100 Activator 99.93% Unkown
HY-RS09553 NR5A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17509 Nr5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23966 Nr5a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr5a1 NCBI NCBI:2516