2. Gene
  3. Tnk1 - tyrosine kinase, non-receptor, 1 Gene

Tnk1 - tyrosine kinase, non-receptor, 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Kos1; Tnk1a; Tnk1b

Gene ID: 83813 | Gene type: protein coding

About Tnk1

Summary

Enables ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of cell growth; and protein autophosphorylation. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; pituitary gland; respiratory system; and thymus. Orthologous to human TNK1 (tyrosine kinase non receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tnk1 Products(1)

mRNA Protein Name
NM_031880.3 NP_114086.3 non-receptor tyrosine-protein kinase TNK1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
12789265 MGI
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12789265 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
12789265 MGI
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
12789265 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
12789265 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
12789265 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

non-receptor tyrosine-protein kinase TNK1

kinase of embryonic stem cells

non-receptor tyrosine kinase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.49% Phase 1
Pre-clinical Phase
Bioactive Molecules (31)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-147316 TP-5801 Inhibitor 99.69% Unkown
HY-12975 AZ6102 Inhibitor 99.65% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.59% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.34% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147886 PARP1-IN-11 Inhibitor 98.58% Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.19% Unkown
HY-137849 RK-582 Inhibitor / Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor / Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnk1 NCBI NCBI:8711