Fdps - farnesyl diphosphate synthase Gene

Rattus norvegicus

Also known as FPS; Ac2-125

Gene ID: 83791 | Gene type: protein coding

About Fdps

Summary

Enables geranyltranstransferase activity. Involved in several processes, including farnesyl diphosphate biosynthetic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of Cholesterol biosynthetic process. Located in mitochondrial matrix and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fdps Products(1)

mRNA	Protein	Name
NM_031840.1	NP_114028.1	farnesyl pyrophosphate synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables geranyltranstransferase activity	IDA IDA: Inferred from direct assay	8188698	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	15473864	RGD
involved in farnesyl diphosphate biosynthetic process	IDA IDA: Inferred from direct assay	8188698	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	1917693	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19716825	RGD
involved in positive regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	18637708	RGD
involved in response to cholesterol	IEP IEP: Inferred from expression pattern	2909544	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	1917693	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	12890564	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15084352	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	2043737	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	8119922	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	8188698	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

farnesyl pyrophosphate synthase

(2E,6E)-farnesyl diphosphate synthase	CR 39
FPP synthase	FPP synthetase
cholesterol-regulated 39 kDa protein	dimethylallyltranstransferase
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranst

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0631	Alendronic acid		≥98.0%	Yes

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106950A	Fosfructose trisodium		≥98.0%	Unkown
HY-148077	Phosphoglycolohydroxamic acid	Inhibitor	≥98.0%	Unkown
HY-B0631S	Alendronic acid-d6		≥98.0%	Unkown
HY-106950	Fosfructose		/	Unkown
HY-RS04853	FDPS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17189	Fdps Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23640	Fdps Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fdps	NCBI	NCBI:2224
Mus musculus	Fdps	NCBI	NCBI:110196

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