2. Gene
  3. Nme2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

Nme2 - NME/NM23 nucleoside diphosphate kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NDKB; nm23-2; p18-12d

Gene ID: 83782 | Gene type: protein coding

About Nme2

Summary

Enables several functions, including identical protein binding activity; intermediate filament binding activity; and kinase activity. Involved in several processes, including cellular response to glucose stimulus; nucleotide metabolic process; and response to growth hormone. Located in mitochondrial membrane and perinuclear region of cytoplasm. Colocalizes with intermediate filament. Human ortholog(s) of this gene implicated in teratoma. Orthologous to several human genes including NME1-NME2 (NME1-NME2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Nme2 Products(1)

mRNA Protein Name
NM_031833.2 NP_114021.2 nucleoside diphosphate kinase B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
17572440 RGD
enables fatty acid binding IPI
IPI: Inferred from physical interaction
18084788 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
1316151 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
1316152 RGD
enables intermediate filament binding IPI
IPI: Inferred from physical interaction
11082283 RGD
enables nucleoside diphosphate kinase activity IDA
IDA: Inferred from direct assay
8142475 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17532299 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9000516 RGD
Biological Process GO Annotation Evidence Reference Source
involved in CTP biosynthetic process IDA
IDA: Inferred from direct assay
1316151 RGD
involved in GTP biosynthetic process IDA
IDA: Inferred from direct assay
1316151 RGD
involved in UTP biosynthetic process IDA
IDA: Inferred from direct assay
1316151 RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17363702 RGD
involved in cellular response to fatty acid IEP
IEP: Inferred from expression pattern
19367376 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19367376 RGD
involved in cellular response to oxidative stress IEP
IEP: Inferred from expression pattern
18442093 RGD
involved in negative regulation of myeloid leukocyte differentiation IDA
IDA: Inferred from direct assay
7737424 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
10069391 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9000516 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
16127721 RGD
Cellular Component GO Annotation Evidence Reference Source
located in intermediate filament IDA
IDA: Inferred from direct assay
11082283 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
11831846 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11082283 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleoside diphosphate kinase B

NDK B

NDP kinase B

NDP kinase alpha

P18

expressed in non-metastatic cells 2

histidine protein kinase NDKB

non-metastatic cells 2, protein (NM23B) expressed in

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N6747 Stauprimide Inhibitor 99.45% Unkown
HY-W591768 (E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide 99.66% Unkown
HY-170436 NFh-NMe-2 Inducer / Unkown
HY-RS09372 NME1-NME2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09373 NME2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19360 Nme2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25852 Nme2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nme2 NCBI NCBI:4831