Wfs1 - wolframin ER transmembrane glycoprotein Gene

Rattus norvegicus

Gene ID: 83725 | Gene type: protein coding

About Wfs1

Summary

Enables several functions, including Calmodulin binding activity; Proteasome binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; protein stabilization; and regulation of transcription, DNA-templated. Is integral component of synaptic vesicle membrane. Used to study cataract; diabetes mellitus; and glucose intolerance. Biomarker of post-traumatic stress disorder and visual epilepsy. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER Transmembrane Glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Wfs1 Products(1)

mRNA	Protein	Name
NM_031823.1	NP_114011.1	wolframin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20160352	RGD
enables calcium-dependent protein binding	IMP IMP: Inferred from mutant phenotype	19292454	RGD
enables calmodulin binding	IMP IMP: Inferred from mutant phenotype	19292454	RGD
enables proteasome binding	IDA IDA: Inferred from direct assay	20160352	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ATF6-mediated unfolded protein response	IGI IGI: Inferred from genetic interaction	20160352	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20160352	RGD
involved in olfactory behavior	IEP IEP: Inferred from expression pattern	11958857	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	19916172	RGD
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20160352	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17110340	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

wolframin

Wolfram syndrome 1 (wolframin)

Wolfram syndrome 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137605	WSF1-IN-1	Inhibitor	99.91%	Unkown
HY-RS15813	WFS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18644	Wfs1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25129	Wfs1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wfs1	NCBI	NCBI:7466

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