NCOA2 - Ncoa2 nuclear receptor coactivator 2 Gene

Rattus norvegicus

Also known as Tif2; Grip1; GRIP-1

Gene ID: 83724 | Gene type: protein coding

About NCOA2

Summary

Enables DNA Polymerase binding activity; PDZ domain binding activity; and nuclear receptor binding activity. Involved in several processes, including male gonad development; positive regulation of female receptivity; and positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including dendritic spine; postsynaptic density; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

NCOA2 Products(1)

mRNA	Protein	Name
NM_031822.2	NP_114010.2	nuclear receptor coactivator 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	11734998	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	20678994	RGD
enables nuclear glucocorticoid receptor binding	IPI IPI: Inferred from physical interaction	9742117	RGD
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	9742117	RGD
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables nuclear thyroid hormone receptor binding	IPI IPI: Inferred from physical interaction	9742117	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15234273	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellum development	IEP IEP: Inferred from expression pattern	10803578	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	16189181	RGD
involved in positive regulation of female receptivity	IMP IMP: Inferred from mutant phenotype	12089347	RGD
involved in positive regulation of glucocorticoid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17481888	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17481888	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	31272713	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	11007883	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor coactivator 2

NCoA-2	glucocorticoid receptor interacting protein 1
transcriptional intermediary factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09090	NCOA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19721	Ncoa2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26217	Ncoa2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	NCOA2	NCBI	NCBI:10499

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