2. Gene
  3. Dvl1 - dishevelled segment polarity protein 1 Gene

Dvl1 - dishevelled segment polarity protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as dvl-1

Gene ID: 83721 | Gene type: protein coding

About Dvl1

Summary

Enables protein kinase binding activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; positive regulation of excitatory postsynaptic potential; and positive regulation of neuron projection arborization. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Colocalizes with microtubule. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dvl1 Products(1)

mRNA Protein Name
NM_031820.1 NP_114008.1 segment polarity protein dishevelled homolog DVL-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16478782 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15608632 RGD
Biological Process GO Annotation Evidence Reference Source
involved in Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
21670302 RGD
involved in dendritic spine morphogenesis IGI
IGI: Inferred from genetic interaction
21670302 RGD
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21670302 RGD
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
15608632 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15608632 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
21670302 RGD
located in growth cone IDA
IDA: Inferred from direct assay
15608632 RGD
located in microtubule IDA
IDA: Inferred from direct assay
15608632 RGD
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15608632 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15608632 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
21670302 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

segment polarity protein dishevelled homolog DVL-1

DSH homolog 1

dishevelled, dsh homolog 1

dishevelled-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04076 DVL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20720 Dvl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27232 Dvl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dvl1 NCBI NCBI:1855